Prognosis of Stage IV Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET) According to the WHO Classification and the Primary Tumor Location

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Introduction: WHO classification of GEP-NET is used to predict prognosis, yet survival within each grade shows wide variation. We hypothesized that primary tumor location may be partially responsible of this variability.

Aim(s): To evaluate the prognosis of stage IV GEP-NET according to WHO classification and primary tumor location.

Materials and methods: We present a subset analysis from RGETNE (registry of Spanish NET Group (GETNE)). The impact of grade was assessed using Cox regression method. Covariates in the model were chromogranin, primary tumor size/location (gastrointestinal, pancreatic or unknown), functionality, ECOG PS and number of metastatic sites. gastrointestinal and grade 1 tumors were used as references categories.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Carmona-Bayonas A

Authors: Carmona-Bayonas A, Jiménez-Fonseca P, Vieitez J, Menendez Prieto M, Soli M,

Keywords: GEP-NET, WHO classification, grade, survival,