RAD001 and Octreotide LAR as first-line treatment of well differentiated neuroendocrine tumors: an I.T.M.O. (Italian Trials in Medical Oncology) group study

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Introduction: RAD001 has shown antitumor activity in pancreatic neuroendocrine tumors (NETs) and it seems to work synergistically with somatostatine analogues.

Aim(s): The primary objective of this multicentric study is to assess the activity and safety of RAD001 and Octreotide LAR as first-line treatment of lung and gastro-entero-pancreatic (GEP) NETs.

Materials and methods: From March 2009 to June 2010, 50 patients (pts) (21 female and 29 male) were treated with RAD001 10 mg/day and Octreotide LAR 30 mg/month, until disease progression and/or unacceptable toxicity. Forty-two pts had a GEP NET and 8 had a lung carcinoid. The median age was 60.5 yrs (range 25-76).

Conference:

Presenting Author:

Authors: Catena L, Biondani P, Fazio N, Giuffrida D, Ricci S,

Keywords: neuroendocrine tumors, everolimus, carcinoid,