Resection at Diagnosis of the Primary Pancreatic Neuroendocrine Tumor in Patients with Unresectable Liver Metastases. A Possible New Approach for a Multimodal Treatment

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Introduction: Pancreatic neuroendocrine tumors (PNETs) present in more than 50% of cases with liver metastases as the only systemic localization. Liver metastases are unresectable in 80% of cases at diagnosis. In the context of metastatic disease, the benefit of primary tumor removal in terms of survival is controversial

Aim(s): To assess the prognostic factors and the potential benefit of primary tumor resection at diagnosis on long-term survival in patients with PNET and synchronous unresectable liver metastases.

Materials and methods: A single-centre series of PNETs presenting with synchronous hepatic unresectable metastases and treated within a framework of a multidisciplinary team was retrospectively analysed.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Bertani E, Chiappa A, Fazio N, Falconi M, Spada F,

Keywords: pancreatic neuroendocrine tumor, synchronous liver metastases, debulking, resection, prognostic factors, survival,