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Retreatment with Peptide-Receptor Radionuclide Therapy: Effects on Long-term Survival, Renal and Bone Marrow Toxicity Using Yttrium-90 vs. Lutetium-177


Introduction: PRRT is an effective treatment for metastatic NETs. The effect of PRRT retreatment is unknown.

Aim(s): To determine efficacy & toxicity of retreatment with PRRT.

Materials and methods: We reviewed patients retreated with PRRT. Patients included: 2 or more cycles of PRRT and retreated >12mths later. We evaluated PFS and toxicity (renal and BM) after initial and retreatment PRRT. Treatment activities were 3.2GBq/cycle for 90Y- and 7.4GBq/cycle for 177Lu-DOTATATE.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Machta J

Authors: Machta J, Caplin M, Toumpanakis C, Mohmaduvesh M, Garcia-Hernandez J,

Keywords: PRRT, retreatment,

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