Somatostatin Receptor PET/CT with Radiolabelled Antagonist Is Twice as Effective as the Agonist for Detecting Liver Metastases: Results of a Phase 1/2 Study Comparing 68Ga-OPS202 with 68Ga-DOTATOC PET/CT in Gastroenteropancreatic NET Patients

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Introduction: 68Ga-DOTATOC PET/CT is a reference method for imaging somatostatin receptor (sstr) expressing neuroendocrine tumors (NET). Presence and extent of liver metastases impact on patient management and prognosis.

Aim(s): To investigate safety and diagnostic accuracy of 68Ga-OPS202, a radiolabelled sstr antagonist for PET/CT imaging of gastroenteropancreatic (GEP) NET (ClinicalTrials.gov NCT02162446).

Materials and methods: Twelve metastatic G1/G2 GEP-NET patients were enrolled in a prospective phase 1/2 imaging study to investigate two single doses of 68Ga-OPS202 (A: 15μg & B: 50μg) in comparison with 68Ga-DOTATOC PET/CT. Scans were reviewed by 2 independent blinded readers. Follow-up imaging and biopsy were used as standard of reference.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Nicolas G

Authors: Nicolas G, Schreiter N, Kaul F, Uiters J, Mena R,

Keywords: Radiolabelled somatostatin antagonist, PET, GEP-NET,