Study Protocol: Prospective, Randomized Controlled Trial on the Effect of Primary Resection in Advanced Metastatic NEN of Pancreas and Midgut (PRESNENAS)

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Introduction: The role of Primary Tumor resection in advanced metastatic NEN is discussed controversely.

Aim(s): To show the benefit of primary resection on progression-free survival in advanced metastatic pancreatic and midgut NET (Stage IV) compared to biotherapy

Materials and methods: Well differentiated neuroendocrine neoplasia (NET, G1, G2, Ki-67<10%) of midgut and pancreas with surgically non-resectable metastases and asymptomatic, resectable primary tumor. Comparison between surgical primary resection plus biotherapy and biotherapy only.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Begum N

Authors: Begum N, Pavel M, Goretzki P, Vonthein R,

Keywords: Prospective Randomized, Controlled Trial, Surgery, Role of Primary Resection,