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Succinate Dehydrogenase B (SDHB) Immunohistochemical Expression in Pancreatic Neuroendocrine Tumours and Correlation with Somatostatin Receptor Immunohistochemistry


Introduction: The established category of succinate dehydrogenase (SDH) deficient neoplasms includes several endocrine tumours with recent evidence that pancreatic neuroendocrine tumours (PNETs) could be included in this tumour group. The SDH complex is composed of four subunits (A-D) but loss of immunohistochemical (IHC) expression for SDHB indicates bi-allelic inactivation of any SDH component and is used as a marker for syndromic disease.

Aim(s): To assess the IHC staining characteristics for SDHB in a cohort of PNETs, and to investigate if any correlation exists between SDHB and somatostatin receptor (SSTR) expression.

Materials and methods: Immunohistochemistry was performed using commercially available antibodies for SDHB (Abcam 21A11AE7), SSTR2A (Abcam UMB1) and SSTR5 (ThermoScientific PA5-34224) on formalin-fixed paraffin embedded tissue from 50 surgically resected PNETs. Positive and negative controls were run on all cases.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Swan N

Authors: Swan N, Nadeem N, Crowley R,

Keywords: succinate dehydrogenase, pancreatic neuroendocrine tumor, somatostatin receptor, immunohistochemistry,

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