Temozolomide as 2.-3. line Treatment of Patients with Poorly Differentiated Neuroendocrine Carcinomas

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Introduction: Knowledge of the clinical efficacy of treatment beyond first line of poorly differentiated neuroendocrine carcinomas (PDEC) is sparse. Temozolomide (TMZ) has shown effect in well-differentiated NET.

Aim(s): Evaluation of the efficacy and tolerability of monotherapy TMZ as 2nd and 3rd line treatment after platin-based chemotherapy in patients with PDEC.

Materials and methods: Patients with PDEC (small cell lung carcinomas excluded). WHO performance status 0-2. Adequate organ function tests. At least one previous platin-containing chemotherapy regimen. Informed consent. TMZ schedule: 200 mg/sqm orally days 1-5 every 28 days. Response evaluation at least every three courses.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Olsen I, Federspeil B, Kjaer A, Palnæs Hansen C, Knigge U,

Keywords: PDEC, poorly differentiated carcinomas, temozolomide, second line treatment,