Ten Years of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs): Evolution of Classification and Correlation with Follow-up in 50 Patients

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Introduction: In the last decade, GEP-NET nomenclature has been twice reviewed. The 2000 WHO classification had poor prognostic power in well-differentiated (WD) neoplasms which led to the introduction of two new important parameters: grade and stage, by ENETS; the former became part of the new 2010 WHO classification.

Aim(s): Considering the recent introduction of grade and stage, their external validation has been called for in the literature. Since these are important tools in the management of patients, our aim was to reclassify retrospectively with grade and stage our series and correlate with follow-up.

Materials and methods: From the histopathology archive at our center, 170 GEP-NETs (1993-2011) were identified. Until now, 50 patients have been reclassified. Mean age at diagnosis was 56 years, F:M ratio was 1:1.2 and mean follow-up was 56 months (2-196).

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Grillo F, Albertelli M, Giannone A, Mastracci L, Annunziata F,

Keywords: neuroendocrine, grade, prognosis,