The Distinctive Character of Micro-Vasculature and Immune Cell Infiltration in Cystic Pancreatic Neuroendocrine Tumors

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Introduction: Hypervascularity is main character of pancreatic neuroendocrine tumors (PanNETs), cystic PanNET (CPanNET) are unique type of PanNETs for which the microenvironment remains unknown.

Aim(s): To compare the microvessel density (MVD), microvessel integrity (MVI) and immune cell infiltration between CPanNETs and solid PanNETs (SPanNETs).

Materials and methods: Data from 301 SPanNET and 36 CPanNET patients at a high-volume institution were evaluated. CD4, CD8, CD11c, CD15, CD20, CD68, CD34 and α-SMA expression were assessed by Immunohistochemistry and Immunofluorescent Double Staining.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Gao H,

Keywords: pancreatic neuroendocrine tumors, cystic, microvascular density, microvascular integrity, tumor-associated macrophage,