The Immunohistochemical (IHC) Expression and Prognostic Value of ER, PR, and HER2/neu in Pancreatic and Small Intestinal Neuroendocrine Tumors

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Introduction: There has been limited study of ER and PR expression in gastrointestinal neuroendocrine tumors (GINETs) and data on HER2/neu overexpression in GINETS has been conflicting.

Aim(s): To assess ER, PR and HER2/neu expression in a cohort of pancreatic and small intestinal NETS and to correlate findings with survival outcomes.

Materials and methods: We identified 77 patients with primary pancreatic (40) or small intestinal (37) NETs diagnosed from 1991 to 2009. Tissue microarrays were constructed and ER, PR, and HER2/neu were assessed via IHC according to current ASCO/CAP guidelines for breast cancer. Survival outcomes were ascertained by retrospective chart review.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Rayson D, Arnason T, Barnes P, Drewniak M, Abdolell M,

Keywords: progesterone receptor, her2/neu, ginets, tissue microarray,