Thoracic and Gastroenteropancreatic (GEP) Neuroendocrine Tumors (NETs) and Ectopic Adrenocorticotropin (ACTH) Syndrome (EAS)

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Introduction: Ectopic Adrenocorticotropin (ACTH) Syndrome (EAS) is associated with a variety of malignancies, mostly of neuroendocrine origin. Several series report on the relative contribution of EAS in the spectrum of Cushing’s syndrome. However, information on the incidence/prevalence of EAS in the setting of patients diagnosed with thoracic or gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) is virtually absent.

Aim(s): Screening of a large consecutive series of Thoracic NET or GEP NET patients for the presence/occurrence of EAS in a retrospective case-record study in a Tertiary academic referral centre.

Materials and methods: Four-hundred and ninety-one patients diagnosed with thoracic or GEP NETs between 2000-2009 were studied. We differentiated between previous, synchronous and metachronous occurrence of EAS. Synchronous EAS was defined as occurring between six months before and six months after first diagnosis of the thoracic or GEP NET. MEN1 and SCLC were excluded.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Kamp K, Alwani A, Feelders R, De Herder W,

Keywords: ACTH, GEP-NETS, Cushing,