Upfront Surgery in Patients with High-Grade GEP NEN and MINEN: A Nordic Multicenter Study of 201 Patients

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Introduction: Surgery is the principal treatment for loco-regional gastroenteropancreatic (GEP) neuroendocrine tumors (NET). However, whether surgery is beneficial in high-grade neuroendocrine neoplasms (NEN) and mixed neuroendocrine-non neuroendocrine neoplasms (MiNEN) is not known.

Aim(s): To investigate if surgery is beneficial in patients with high-grade (Ki-67>20%) GEP NEN and GEP MiNEN stage I-III or stage IV.

Materials and methods: Retrospective study from 8 Scandinavian centers. Overall survival (OS) and progression free survival (PFS)/disease free survival (DFS) were analyzed by Kaplan-Meier estimate. Prognostic factors were evaluated using COX regression.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Pommergaard H

Authors: Pommergaard H, Nielsen K, Sorbye H, Federspiel B, Tabaksblat E,

Keywords: surgery, neuroendocrine carcinoma, MiNEN, neuroendocrine neoplasms, survival, gastroenteropancreatic,