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Urinary 5-hydroxyindoleacetic Acid In Serotonin-Producing Neuroendocrine Tumors: Correlation with Disease Features and Patients' Survival


Introduction: Urinary 5-hydroxyindoleacetic acid (U-5HIAA) is a useful marker for serotonin-producing neuroendocrine tumors (NETs). Its prognostic role, however, is yet to be fully elucidated.

Aim(s): To evaluate U-5HIAA's role as a prognostic marker and its relation to disease features.

Materials and methods: Two-hundred and seven patients were included. Rates of flushing and bowel movements, chromogranin-A (CgA) levels and radiological data, were recorded. Patients were grouped, based on 5HIAA levels (Group 1: ≤1x upper limit of normal (ULN), 2: 1-5x ULN, 3: 5-10x ULN, 4: >10xULN).

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Bartholomew T, Garcia-Hernandez J, Rossi R, Braude D, Mullan M,

Keywords: U-5HIAA, symptoms, prognosis, survival,

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