Abstract library

20 results for "Marino".
#99 Gene mutations and Hypoxia Inducible Factor (HIF-1) expression as prognostic-predictive factors in pheochromocytomas/paragangliomas (P/P)
Introduction: P/P are rare tumors sporadically associated with familial disorders. In advanced/unresectable disease, no standard treatment has so far been well established. Recently a mutation of some genes (SDHB, SDHC, SDHD) involved in the pathogenesis of familial P/P was discovered. These mutations are often associated with an over-expression of HIF-1, which plays a central role in angiogenesis and cell proliferation. This pathway is known to be inhibited by some targeted therapies, such as sunitinib or sorafenib.
Conference: 7th Annual ENETS Conference (2010)
Category: Basic
Presenting Author: Emilio Bajetta
#100 Mammalian target of rapamycin (mTOR) expression analysis and therapeutic approach in lung and gastroenteropancreatic poorly differentiated endocrine carcinoma (PDEC)
Introduction: PDEC clinically include gastroenteropancreatic PDEC, small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma (LCNEC). These tumors are clinically similar and aggressive and they are usually treated with platinum compounds. mTOR signalling pathway has emerged as a promising target for well-differentiated endocrine carcinoma therapy. Because of varying behavior, PDEC are usually excluded from clinical trials employing the mTOR inhibitor RAD001.
Conference: 7th Annual ENETS Conference (2010)
Category: Basic
Presenting Author: Emilio Bajetta
#160 The role of T-type calcium channels in medullary thyroid carcinoma (MTC): T-type calcium channel blockers inhibit hormone secretion and induce apoptotic cell death in a human MTC cell line
Introduction: Medullary thyroid carcinoma (MTC) accounts for approximately 5-10% of thyroid cancers. In the case of tumors limited to the thyroid gland, the prognosis is generally favorable, whereas 5-year survival averages only 40% in patients with metastatic disease. In these patients, conventional chemotherapy only occasionally leads to a complete response and partial responses are observed in less than 30% of the cases. Therefore, intense efforts are currently directed toward the identification of new druggable targets for the treatment of this devastating disease.
Conference: 7th Annual ENETS Conference (2010)
Category: Basic
Presenting Author: Dr Rosario Pivonello
#405 EUS-FNA for Pancreatic Neuroendocrine Tumors: A Single Referral Centre Experience
Introduction: Pancreatic neuroendocrine tumors (PNET) are not an uncommon finding and recent data show the importance of EUS in diagnosis of PNET.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Franco Grimaldi
Keywords: EUS-FNA, GEP-NET
#518 CK19 and KIT Immunostaining is a Useful Adjunct to Ki-67-Based Grading of Pancreatic NET: A Study on Matched Cytological and Histological Samples
Introduction: Pancreatic neuroendocrine tumors (NET) are rare neoplasms. Recent evidence suggests that Ki-67 staining predicts their behavior. Even more recently, a prognostic role has been proposed also for CK19 and KIT. This panel might guide patient management. CK19 and KIT have not yet been evaluated on NET on Fine needle aspiration samples (FNAs).
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Prof. Giancarlo Troncone
Keywords: FNA, pancreas, NET, Ki-67, Kit, CK19
#637 Prognostic Factors Affecting Outcome in Patients with Liver Resection of Neuroendocrine Hepatic Metastasis
Introduction: Neuroendocrine (NE) malignant neoplasms commonly metastasize to the liver, which can be the only site of metastatic disease. The clinical course of patients who undergo surgical resection of hepatic NE metastases varies widely and the reported factors affecting survival have not been identified.
Conference: 10th Annual ENETS Conference (2013)
Category: Epidemiology/Natural history/Prognosis - Prognosis
Presenting Author: Professor Franco Lumachi
#701 High Expression of Mammalian Target of Rapamycin (mTOR) in NF1-Related Periampullary Neuroendocrine Tumors
Introduction: Neurofibromatosis type 1 (NF1) is a rare inherited disorder associated with cutaneous lesions and neoplasms in the nervous and gastroenteropancreatic systems, including periampullary NETs. NF1-coded protein, neurofibromin, is a tumor suppressor that negatively regulates the mammalian target of rapamycin (mTOR). Preclinical in vitro and in vivo studies demonstrated a constitutive activation of mTOR pathway associated with significant antineoplastic effects of mTOR inhibitors in NF1-related glial tumor models.
Conference: 10th Annual ENETS Conference (2013)
Category: Surgical treatment
Presenting Author: MD Paola Razzore
#843 Lymph Node Involvement to Predict Survival in Pulmonary Neuroendocrine Tumors – A Single Center Experience
Introduction: Typical (TC) and Atypical carcinoid (AC) tumors are well-differentiated neuroendocrine tumors of the lung.
Conference: 11th Annual ENETS Conference (2014)
Category: Epidemiology/Natural history/Prognosis - Prognosis
Presenting Author: Dr Vanessa E Clay
Authors: Clay V E, Stein R, Piarino E, Lam D, ...
Keywords: lung
#856 DAXX and ATRX Loss Defines Chromosomal Instability and Poor Outcome in Pancreatic NET
Introduction: Chromosomal Instability (CIN) has been reported in pancreatic neuroendocrine tumors (pNETs) with poor outcome. However, no specific genetic background has been associated with CIN. Whole exome sequencing revealed mutations in DAXX (Death domain associated protein gene) and ATRX (ATR-X gene) in 40% of pNETs. DAXX and ATRX mutations in pNETs are associated with Alternative Lengthening of Telomeres (ALT) activation.
Conference: 11th Annual ENETS Conference (2014)
Category: ...none of the below
Presenting Author: PhD Ilaria Marinoni
Keywords: pNET, Daxx, Atrx, ALT, CIN
#945 Interference of Nutrient/Oxygen Availability with mTOR Activation and Inhibition in Lung Carcinoids: A Tissue and Cellular Study
Introduction: MTOR is capable of coupling cellular nutrient sensing to metabolic homeostasis. However, little is known of the interactions between cancer‐specific metabolic pathways and profiles of responsiveness to mTOR inhibition in neuroendocrine tumors.
Conference: 11th Annual ENETS Conference (2014)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Prof Marco Volante
Authors: Rapa I, Giorcelli J, Votta A, Marino G, ...
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