Abstract library

4 results for "Robo1".
#1539 Slit-Robo Signaling Links to Ras Activity to Suppress Metastasis and Is Associated with Time-to-Progression in Pancreatic Neuroendocrine Tumors
Introduction: mRNA signatures of distinct metastatic phenotypes of pancreatic NETs (pNETs) exhibit differences in several components of the Slit-Robo axon guidance system.
Conference: 13th Annual ENETS conference (2016)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: PD Dr. med. Christian Fischer
#770 The Axon Guidance Molecules Slit2 and Robo Control Motility and Growth of Pancreatic Neuroendocrine Tumor Cells
Introduction: Dense vascularization and high frequency of metastasis in pancreatic neuroendocrine tumors (pNET) suggest a central role for the interaction of tumor cells and vessels. Slit2 and its receptors Robo1 and Robo4 act as guidance cues in neurogenesis, angiogenesis and epithelial morphogenesis, and hence represent attractive candidate regulators at the tumor cell/stroma interface.
Conference: 10th Annual ENETS Conference (2013)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: Dr Christian Fischer
#1736 Slit2-Robo1 Signaling Activates Ras to Suppress Metastasis and Is Associated with Time-To-Progression in Pancreatic Neuroendocrine Tumors
Introduction: Transcriptom analysis revealed that mRNA signatures of distinct metastatic phenotypes in pancreatic NETs (pNETs) exhibit differences in components of the Slit-Robo pathway.
Conference: 14th Annual ENETS conference (2017)
Category: Basic Science - Signaling pathways, receptors, biomarkers
Presenting Author: PD Dr. med. Christian Fischer
#1490 Even Malignant Appendiceal Neuroendocrine Tumors Exhibit No Recurrent Chromosomal Alterations
Introduction: Neuroendocrine tumors (NETs) of the midgut are located in the ileum (iNET), caecum or appendix (aNET). Despite of the similar origin, NETs of the ileum and the appendix behave remarkably different. iNETs show high malignant potential, which manifests with early lymph node or liver metastases. Genetically, the loss of chromosome 18 (Ch18) in 60-74% of cases is the most frequent alteration in iNETs. aNETs are often incidental findings, rarely show metastases, and no chromosomal alterations are known.
Conference: 13th Annual ENETS conference (2016)
Category: Basic Science - Genetics, epigenetics, miRNAs
Presenting Author: Maike Nieser
Keywords: NET
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