Abstract library

Introduction: NETs of unknown primary account for 10-15% of NETs. There is limited published literature on this group of NETs.

Conference: 10th Annual ENETS Conference 2013 (2013)

Category: Surgical treatment

Presenting Author: Dr Raj Srirajaskanthan

Authors: Srirajaskanthan R, Quaglia A, Vivian G, Mulholland N, ...

Keywords: unknown primary, survival

Introduction: Neuroendocrine neoplasms of unknown primary (NENs-UP) account for 10-13% of all NENs and show different biologic behavior, histologic appearance and clinical outcome.

Conference: 13th Annual ENETS conference 2016 (2016)

Category: Epidemiology/Natural history/Prognosis - Descriptive epidemiology

Presenting Author: dr Sara Massironi

Authors: Massironi S, Fanetti I, Cavalcoli F, Zilli A, ...

Keywords: Neuroendocrine tumors, unknown primary

Introduction: Recent studies suggest that capsule endoscopy (CE) should be implemented in diagnostic work-up in patients suspected to have small bowel (SB) tumors. SB accounts for the primary tumor site in 80%-85% of patients with intestinal neuroendocrine tumors (NET). In 10%-15% of patients diagnosed with metastasized NET, the primary tumor site remains obscure.

Conference: 10th Annual ENETS Conference 2013 (2013)

Category: Imaging (radiology, nuclear medicine, endoscopy)

Presenting Author: PhD Panagiotis Drymousis

Authors: Drymousis P, Martin J, Smith G, Kinross J, ...

Keywords: capsule endoscopy, small bowel NETs, NETs of unknown primary

Introduction: Neuroendocrine tumors of unknown primary site (NET UPS) are rare and heterogenous tumors with poor prognosis. There is little information available on the treatment and prognosis.

Conference: 10th Annual ENETS Conference 2013 (2013)

Category: Surgical treatment

Presenting Author: M.D., Ph.D. Hyun-Jeong Shim

Authors: Shim H J, Kim D, Hwang J E, Lee K H, ...

Keywords: neuroendocrine tumor, unknown primary site

Introduction: Merkel cell carcinoma (MCC) is a rare aggressive cutaneous neuroendocrine carcinoma with a high rate of metastasis. Approximately 5% of MCC are found in the lymph nodes (LNs) without a primary tumor on the skin.

Conference: 17th Annual ENETS Conference 2020 (2020)

Category: Case reports

Presenting Author: Dr Mohammed Alaeddine Saidi

Authors: Saidi M A, Ghomari S, ...

Keywords: merkel cell carcinoma, lymph node metastasis, unknown primary, surgery, radiotherapy

Introduction: The existence of primary lymph node gastrinoma has been proposed but is controversial. We report two cases (Case A - 37-year-old male, Case B - 43-year-old male) of apparent primary lymph node gastrinoma.

Conference: 8th Annual ENETS Conference (2011)

Category: Clinical

Presenting Author: Dr Richard W Carroll

Authors: Carroll R W, Martin J L, Tan T, Goldstone A P, ...

Keywords: primary lymph node gastrinoma, gastrinoma of unknown primary site, lymph node metastases

Introduction: Recent studies suggest that video capsule endoscopy (CE) should be implemented in diagnostic work-up in patients with suspected small bowel tumors. Small bowel is the primary site in 80%-85% of patients with intestinal neuroendocrine tumors (NET). In 10%-15% of patients diagnosed with metastasized NET, the localization of the primary tumors remains obscure.

Conference: 11th Annual ENETS Conference 2014 (2014)

Category: Imaging (radiology, nuclear medicine, endoscopy)

Presenting Author: Helen Miller

Authors: Martin J, Smith G, Drymousis P, Frilling A, ...

Keywords: NET, unknown primary, capsule endoscopy

Introduction: Determining the origin of a neuroendocrine tumor (NET) of unknown primary can be challenging. Liver metastases can originate from any organ in the body, while pulmonary NETs can be metastases but also primary tumors. This especially holds true for Multiple Endocrine Neoplasia Type 1 patients, who often have multiple primary pancreatic and intestinal NETs. It is important to know the origin of the primary tumor since resection or ablation is crucial in case of treatment with curative intent. Furthermore, the site of origin determines prognosis, treatment options and eligibility for clinical trials.

Conference: 17th Annual ENETS Conference 2020 (2020)

Category: Basic Science - Genetics, epigenetics, miRNAs, Omics

Presenting Author: Wenzel M Hackeng

Authors: Hackeng W M, Geisenberger C, de Leng W W J, Morsink F H, ...

Keywords: Methylation profiling, Neuroendocrine tumor, Machine Learning, Unknown Primary

Introduction: Primary neuroendocrine tumors (NETs) are rare and often difficult to detect, leading to diagnosis late in their development. Cases in which the primary cannot be located are denoted as CUP-Syndrome.

Conference: 8th Annual ENETS Conference (2011)

Category: Basic

Presenting Author: Dipl. Biol. Nicole Posorski

Authors: Posorski N, Kaemmerer D, Ernst G, Hoersch D, ...

Keywords: neuroendocrine tumors, microarray analysis, gene expression, CUP, carcinoma of unknown primary

Introduction: Based on epidemiological data from SEER 1950-1999, 22.4% cases of non-carcinoid second primary tumors have been described in patients diagnosed with neuroendocrine tumors. The incidence of this type of tumors varies, depending on the series assessed.

Conference: 7th Annual ENETS Conference (2010)

Category: Clinical

Presenting Author: MD Juan Manuel OConnor

Authors: Pesce V, OConnor J, Mendez G, Bestani C, ...

Keywords: neuroendocrine tumor, second primary tumors