Antitumor Treatment with Lanreotide Autogel 120 mg (LAN) for Enteropancreatic (EP-)NET: Update from the CLARINET Open-Label Extension (OLE) Study Abstract #1188

Introduction: In CLARINET, LAN had significant antitumour effects vs placebo (PBO) on metastatic G1/G2 EP-NETs, liver burden ≤ and >25%, and 96% SD prior to LAN.
Aim(s): To characterise LAN antitumour activity further in the OLE.
Materials and methods: Core study (n=204): patients had metastatic well/moderately differentiated non-functioning EP-NETs with Ki-67 <10%, no prior medical therapy within 6 mo, documented PD/SD status, and received LAN/ PBO for 96 wks or until PD (RECIST 1.0) or death. OLE (n=88): patients entered the OLE if they had SD at end of core study or they had PD on PBO during core study; LAN is administered until (further) PD or death (NCT00842348).
Conference: 12th Annual ENETS Conference 2015 (2015)
Category: Medical treatment - SMS analogues, interferon
Presenting Author: Martyn Caplin

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