Telotristat Etiprate (TE) in a Cohort of Carcinoid Heart Disease Patients in Two Phase 2 Trials Abstract #870

Introduction: Serotonin is a key mediator of carcinoid syndrome (CS). High levels of urinary 5-hydroxyindoleacetic acid (u5-HIAA, a serotonin metabolite) have also been linked with carcinoid heart disease (CaHD). Telotristat etiprate (TE), a novel, oral inhibitor of serotonin synthesis, is in Phase 3 development for the treatment of CS.
Aim(s): There is limited information on the potential benefits of serotonin reduction in patients (pts) with CaHD.
Materials and methods: We retrospectively reviewed data on all pts who received TE in Phase 2 trials for CS. In pts with prior history of CaHD, we assessed baseline characteristics, reductions in u5-HIAA, adverse events (AEs), and procedures while on TE.
Conference: 11th Annual ENETS Conference (2014)
Category: Medical treatment - Others
Presenting Author: Darren Wheeler

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