ENETS Abstract Search

Activation of EGFR and c-Met Signaling Pathways in Well-Differentiated Neuroendocrine Tumors of the Small Intestine

#509

Introduction: The biological mechanisms driving midgut carcinoid (MGC) are unknown. The purpose of this study is to explore the role of EGFR and c-Met signaling pathways in the pathogenesis.

Aim(s): To determine the presence of activated EGFR and c-met in MGC.

Materials and methods: A tissue microarray of primary and metastatic MGCs was evaluated by immunohistochemistry for expression of amphiregulin, Her2/neu, EGFR, phosphorylated –EGFR (p-EGFR), c-Met and phosphorylated c-Met (p-c-Met). The microarray contains nine cases with primary SI-NET and liver metastasis, 20 with primary tumor only, and six with liver metastasis only. Activation of EGFR and c-Met was compared between the primary tumors and liver metastases.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Liu E, Mikhitarian K, Revetta F, Shi C,

Keywords: carcinoid, EGFR, c-met, immunohistochemistry,

To read the full abstract, please log into your ENETS Member account.