Additional Value for Urinary 5-Hydroxyindoleacetic Acid as Prognostic Marker in Neuroendocrine Tumors?

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Introduction: 5-Hydroxyindoleacetic Acid (5-HIAA) is of value for diagnosis of NETs and correlates with severity of carcinoid syndrome. However its value for determining prognosis is uncertain, particularly in combination with other biomarkers

Aim(s): to determine prognostic value of 5-HIAA for overall survival (OS) in patients with a midgut NET or unknown primary and to compare prognostic value with patient characteristics, grade, stage, chromogranin A (Cga) and neuron-specific enolase (NSE)

Materials and methods: data were collected from all patients with a midgut NET or a NET from unknown primary with available 5-HIAA in 24 hour urine samples. Results were stratified for 5-HIAA and CgA: <2x upper limit of normal (ULN), 2-10x ULN or >10x ULN. For NSE this was reference range or >1xULN. OS was compared using a Kaplan Meijer with log rank test and hazard ratios were calculated using Cox-regression for univariate and multivariate analyses

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Zandee W

Authors: Zandee W, Kamp K, Van Adrichem R, Feelders R, De Herder W,

Keywords: prognosis 5-HIAA,