An Analysis of Toxicity after Peptide Receptor Radionuclide Therapy (PRRT) in 807 Patients: Determination of the Limited Predictive Role of Clinical Factors

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Introduction: PRRT with 90Y-octreotide (Y) and 177Lu-octreotate (Lu) is well-tolerated.

Aim(s): To identify clinical parameters predictive of long-term renal and hematological toxicity.

Materials and methods: Eight-hundred and seven patients from IEO-Milan (1997-2013). Seven-hundred and ninety-three (98%) with Lu, Y or both (Lu: 34.4%, Y: 44.4%, Lu+Y: 19.5%), 2% combinations of PRRT + other agents. Follow-up: 30 months (1-180). Parameters included renal and marrow risk factors. Analysis: multiple regression, modeling.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Bodei L

Authors: Bodei L, Kidd M, Grana C, Severi S, Modlin I,

Keywords: NET, PRRT, risk, toxicity,