Introduction: The neuroendocrine tumors (NETs) of the rectum are rare but increasing in incidence, by means of improved endoscopic techniques and histological reporting. They often occur as small polypoid lesions and G1, and in most cases an incidental finding at endoscopy.
Aim(s): Since there is no data on molecular alterations leading to development and progression in rectum NETs, this study aims to identify characteristic gene expression patterns.
Materials and methods: We analyzed mRNA transcripts of 770 genes of 8 well-differentiated rectum NETs versus 2 healthy rectum tissue samples by multiplex gene expression analysis using the Nanostring® nCounter® system. Differentially expressed genes were allocated to signaling pathways by gene set analysis and Gene Ontology (GO) overrepresentation analysis.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - Signaling pathways, receptors, biomarkers
Presenting Author: Dr. Franziska Briest
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Introduction: Neuroendocrine tumors (NET), especially well-differentiated endocrine tumors, are often slow-growing, indolent, and may not become clinically apparent until the manifestations of metastatic spread or carcinoid syndrome. Results of previous studies demonstrated that phosphoinositide 3-kinase (PI3K)/Akt/mTOR signaling pathway may be activated in the great majority of NET cells. mTOR inhibitors are therefore considered effective anti-tumor reagents but they may also induce an activation of PI3K/Akt and MAPK pathways as a compensatory action and reduce their own anti-tumor activities.
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Conference: 8th Annual ENETS Conference (2011)
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Conference: 10th Annual ENETS Conference 2013 (2013)
Category: Non digestive NETs (bronchial, MTC, pheochromocytoma)
Presenting Author: MSc Dorian Swarts
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Conference: 13th Annual ENETS conference 2016 (2016)
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