Analysis of Gene Expression Patterns of Rectum Neuroendocrine Tumors (NET) Versus Healthy Tissue Reveals Alterations in the MAPK and WNT Signaling Pathways

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Introduction: The neuroendocrine tumors (NETs) of the rectum are rare but increasing in incidence, by means of improved endoscopic techniques and histological reporting. They often occur as small polypoid lesions and G1, and in most cases an incidental finding at endoscopy.

Aim(s): Since there is no data on molecular alterations leading to development and progression in rectum NETs, this study aims to identify characteristic gene expression patterns.

Materials and methods: We analyzed mRNA transcripts of 770 genes of 8 well-differentiated rectum NETs versus 2 healthy rectum tissue samples by multiplex gene expression analysis using the Nanostring® nCounter® system. Differentially expressed genes were allocated to signaling pathways by gene set analysis and Gene Ontology (GO) overrepresentation analysis.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Briest F

Authors: Briest F, Hummel M, Grabowski P, Arsenic R,

Keywords: rectum neuroendocrine tumors, NET, MAP kinase, gene expression analysis, Wnt signaling,