Analysis of mTOR, CXCR4 and PD-1 Checkpoint Pathways in Merkel Cell Neuroendocrine Carcinomas: Correlations with Prognosis and Viral Status

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Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine tumor. Prognostic factors currently included in the reference AJCC classification are mainly clinical.

Aim(s): Our objectives were to analyse clinicopathological prognostic factors and molecules of 3 main signaling pathways (mTOR, CXCR4 and PD1/PDL1) potentially involved in MCCs. Activity of PD1/PD-L1 inhibitors has been recently shown.

Materials and methods: In a multicenter retrospective study, we collected 136 tumor samples included in paraffin from 122 patients between 2005 and 2013. We analyzed histological characteristics on H&E-whole slides, and immunochemical characteristics on Tissue Microarrays. We collected clinical data and follow-up for 77 patients.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Benhamou J, Deschamps L, Vergier B, Pham-Ledard A, Carlotti A,

Keywords: Merkel cell carcinoma, mTor, CXCR4, PD-L1,