Introduction: Gastro-entero-pancreatic neuroendocrine neoplasms（GEP-NENs） are intractable, heterogeneous tumors, characterized by secreting serotonin metabolites or polypeptide hormones. There are currently little targets for the diagnosis and treatment of GEP-NENs. Serum circulating exosomes (scrExos) are extracellular vesicles secreted by all cells especially neuroendocrine cells to some extent, circulating in the blood with proteins and nucleic acids.
Aim(s): To explore the proteomics of scrExos as potential diagnostic and theraputic target in GEP-NENs.
Materials and methods: A total of 8 GEP-NENs patients and 8 healthy subjects were involved to detect the discrepant proteins in scrExos by iTraq analyses. Then, cancer tissues and peri-cancer tissues (>5cm distant from cancer) of 43 GEP-NENs patients were included to explore the biofunction of target protein.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - Genetics, epigenetics, miRNAs, Omics
Presenting Author: Bai Jian-An
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