Analysis of the Undifferentiated Neuroendocrine Carcinomas (grade 3) from the Czech Neuroendocrine Registry

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Introduction: GEP NETs WHO classification 2010 describes well-differentiated tumors grade 1 and grade 2 and neuroendocrine carcinomas grade 3 with high mitotic index over 20 mitoses /10 HPF or Ki 67 over 20%. Pulmonary neuroendocrine tumor classification 2004 describes typical and atypical carcinoid tumor and small-cell and large-cell neuroendocrine carcinomas with mitotic index over 10 mitoses/ 10 HPF.

Aim(s): We analyzed G3 patients in the NET Registry, according to their diagnosis, histological type, localization, treatment and survival.

Materials and methods: In the Czech Neuroendocrine Registry, we identified these grade 3 neuroendocrine carcinoma patients. We found 74 G3 patients from 799 valid registered patients. Statistical analyses were done for these patients and compared to G1 and G2 patients.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Sedlackova E, Barkmanova J, Louthan O, Linke Z,

Keywords: neuroendocrine carcinoma, grade 3, neuroendocrine registry ,