Angiogenesis markers after hepatic artery embolization of liver metastases in patients with neuroendocrine tumors

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Introduction: In the event of diffuse hepatic metastases, hepatic artery embolization (HAE) can be a successful treatment option in patients with well-differentiated neuroendocrine tumors (WNET). Although there are suggestions of activation of the angiogenesis by HAE, no information is available about the development of growth factors caused by vascular obstruction with embolization.

Aim(s): To investigate angiogenesis activity following embolization by measuring of vascular endothelial growth factor (VEGF), endothelin-1 (ET) and C-terminal pro-Endothelin-1 (proET). To examine necrosis activity MonoTotal (MT), a cytokeratin marker, was measured.

Materials and methods: Between 2003 and 2008, 12 patients (M/F: 6/6, age (mean ± SD): 59 ± 9 years) were treated with transcatheter embolization. Blood was obtained before embolization and the days following this treatment during hospitalization. VEGF and ET were measured with ELISA kits (R&D Systems, Minneapolis, USA) and proET levels was measured with an immunoassay (BRAHMS AG; Hennigsdorf, Germany). MT was measured with an IRMA-assay (IDL Biotech AB, Bromma, Sweden).

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Korse C, Bonfrer J, Taal B,

Keywords: neuroendocrine tumors, hepatic artery embolization, angiogenesis, necrosis, VEGF, Endothelin, pro-Endothelin, cytokeratin, MonoTotal,