Application of Parametric Contrast-Enhanced Ultrasound for Early Treatment Response Evaluation in Metastatic Hepatic Neuroendocrine Neoplasm

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Introduction: Since shrinkage of lesions in patients with metastatic hepatic neuroendocrine neoplasm (MHNEN) receiving systemic therapy is rarely observed,limit of RECIST for evaluating treatment response gradually emerged.

Aim(s): To investigate the feasibility of parametric contrast-enhanced ultrasound (CEUS) for early therapeutic response evaluation.

Materials and methods: 13 MHNEN patients who received systemic therapy underwent baseline ultrasound,2D-CEUS and 3D-CEUS pre-treatment and post-treatment regularly(after 1/2,1,2 and 3 period of treatment).CEUS raw data was analyzed to render time-intensity curve and extract parameters:peak intensity(PI),area under curve(AUC) and slope.Treatment response was assessed with CECT according to RECIST.Relation between percentage of parameters changed (Δparameter%) and response,distinction between 2D and 3D-CEUS were analyzed.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Lin X

Authors: Lin X, Chen J, Xu M, Xie X, Zhang Y,

Keywords: neuroendocrine neoplasm,hepatic,parametric CEUS,early response evaluation.,