Are eIFs Ingredients for Neuroendocrine Tumorigenesis?

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Introduction: Neuroendocrine tumors (NETs) develop in almost any organ, therefore they are a very heterogeneous group of tumors. One of the major activities in every cell is the translation of mRNA to the corresponding protein, which plays an important role in cancer development. Crucial for this translation process are eukaryotic initiation factors (eIFs), which are themselves regulated by the mammalian target of Rapamycin (mTOR)-pathway. Mutation or deregulated expression of eIFs influences cell growth and proliferation, contributing to carcinogenesis. The incidence of NETs has increased fivefold over the last three decades.

Aim(s): We aimed at investigating the contribution of eIFs to NETs.

Materials and methods: NETs and their metastases from 3 individuals were analyzed on protein expression level for eIFs and mTOR members by Western Blot. Additionally we have investigated various eIF subunits in gastroenteropancreatic NETs and neuroendocrine carcinomas by immunohistochemistry. Normal adjacent tissue served as control.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Haybaeck J

Authors: Gantenbein N, Smolle E, Thalhammer M, Kornprat P, Lackner C,

Keywords: NETs, mTOR, eukaryotic translation initiation,