Aspirin Inhibits Cell Viability and mTOR Signalling in Neuroendocrine Tumor Cells Abstract #739

Introduction: Patients with multiple endocrine neoplasia (MEN) type 1 develop pancreatic NETs as well as thymic and bronchus carcinoids. Aspirin has been reported to inhibit mTOR signalling and exhibit antitumoral activity in colorectal cancer cells. So far, no data with aspirin on NETs have been published.
Aim(s): To characterize a potential role of aspirin as prophylactic antitumoral drug in MEN-1 patients.
Materials and methods: Human pancreatic neuroendocrine BON1 cells and bronchopulmonary H727 cells were treated with different concentrations of aspirin (0.001mM - 5mM) and the effects on cell viability and various signalling pathways (Western Blot analysis) were examined.
Conference: 10th Annual ENETS Conference (2013)
Category: Epidemiology/Natural history/Prognosis - Descriptive epidemiology
Presenting Author: MD Matilde P Spampatti

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