Assocation Between miRNAs and HDACs in Pancreatic Neuroendocrine Tumors

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Introduction: Epigenetic factors are essentially involved in carcinogenesis, tumor promotion and chemo resistance with their major key players of miRNAs and histone deacetylases (HDACs). As shown by own theoretical databank analysis, the crosstalk between miRNAs and HDACs are relevant in different human chronic diseases and cancerogenic pathways.

Aim(s): The aim of our study was the investigation of a well-defined subset of “pro-proliferative” miRNAs, which are related to expression of HDACs and clinical parameters in pancreatic neuroendocrine tumors (pNETs).

Materials and methods: We investigated the expression levels of miR132-3p, miR145-5p, miR183-5p, miR34a-5p and miR449a in 57 pNETs resected between 1997 and 2015. These findings were linked to the immunhistochemical expression pattern of members of the four HDAC classes on human tissue microarrays. All pNET cases were clinically and pathologically characterized according to published guidelines.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Swierczynski S, Klieser E, Urbas R, Stättner S, Primavesi F,

Keywords: Epigenetics, miRNA, histone deacetylases, pancreatic neuroendocrine tumor,