Introduction: Pancreatic neuroendocrine malignancy is rising up in the last decade. Despite surgical resection and palliative therapy, an effective therapy has not been developed yet.
Aim(s): Here, we aim to investigate the role of autophagy and its involvement in cell death of pancreatic neuroendocrine tumor cells and stellate cells.
Materials and methods: BON1, QGP-1 (PNET cells) and HPSC 2.2 pancreatic stellate cells were treated for 24 h with 100 pM bafilomycin, an inhibitor of autophagy, and 10 nM panobinostat, an autophagy inducer. The cell growth/viability was monitored with xCelligence. RT-qPCR and Western Blot were performed to analyze autophagy markers.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: PhD Pietro Di Fazio
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