Blood-Based Prognostic Biomarkers in Neuroendocrine Tumour: A Retrospective Study Abstract #1311

Introduction: Markers of systemic inflammation –such as the neutrophil:lymphocyte ratio (NLR), platelet:lymphocyte ratio (PLR) and lymphocyte:monocyte ratio (LMR) - have been shown to correlate with poor prognosis in multiple solid organ tumours. Analysis of CLARINET showed no significant association between NLR and progression-free survival.
Aim(s): To investigate the prognostic value of NLR, PLR and LMR in patients with metastatic NET.
Materials and methods: We identified patients with histologically diagnosed NET, who had a full blood count in the 7 days prior to biopsy or resection. The prognostic impact of NLR – NLR>5 vs NLR<5 (NLR5) and NLR>3 vs NLR<3 (NLR3), PLR (PLR>median vs PLR<median) and LMR (LMR>median vs LMR<median) on overall survival (OS) was assessed using the log-rank test.
Conference: 13th Annual ENETS conference (2016)
Category: Biomarkers
Presenting Author: Dr David Chan
Keywords: NLR, biomarker

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