Bronchial Carcinoid Response to mTOR Inhibitors Depends on mTOR Expression Levels Abstract #429

Introduction: Bronchial carcinoids (BCs), originating from endocrine cells dispersed in the respiratory epithelium, can be divided into typical (TBC) and atypical (ABC). TBC are less aggressive, smaller, and much less likely to metastasize, while ABC are more aggressive and metastasize. mTOR has a central role in regulating cell growth, metabolism, and apoptosis. A differential mTOR activation in BCs has been previously demonstrated, suggesting that mTOR pathway might play a predictive role in patients eligible for mTOR-targeted therapies
Aim(s): To evaluate the effects of mTOR inhibitors on human BCs cell lines.
Materials and methods: NCIH720 (ABC) and NCIH727 (TBC) cells were treated with Everolimus or with NVP-BEZ 235, a dual PI3K/mTOR inhibitor. Cell viability, caspase activity and cell cycle progression were evaluated after 72 h.
Conference: 9th Annual ENETS Conference (2012)
Category: Basic
Presenting Author: Dr Teresa Gagliano
Keywords: BC, mTOR

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