C-Reactive Protein As a New Prognostic Factor for Overall Survival in Patients with Pancreatic Neuroendocrine Neoplasia

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Introduction: For many cancer entities, inflammation has been shown to play an important role in pathogenesis and progression.

Aim(s): To investigate the association between preoperative plasma levels of C-reactive protein (CRP) and overall survival (OS) in patients with pancreatic neuroendocrine neoplasia (pNEN).

Materials and methods: A prospective database of patients with pNENs was retrospectively analysed with focus on initial preoperative CRP blood levels (<5 mg/l vs ≥5 mg/l). Among 149 patients with sporadic pNEN, Kaplan-Meier method and Cox regression were used to evaluate the relationship between CRP and clinical outcome, defining overall survival as primary endpoint. Possible association between CRP-levels and the other prognostic factors was investigated via crosstabulation and Pearson-χ2-test.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fendrich V

Authors: Fendrich V, Wiese D, Kampe K, Heverhagen A, Waldmann J,

Keywords: CRP, prognosis, pNEN, survival,