Introduction: Altered expression of Insulin-like Growth Factor-1 (IGF-1), its receptor (IGF-1R), Connective Tissue Growth Factor (CTGF) and Hypoxia Factor-1 (HIF-1), has been implicated in tumorigenesis. These factors have not been studied systematically in Pulmonary Carcinoids (PCs).
Aim(s): To examine IGF-1, IGF-1R, CTGF and HIF-1 expression in PCs, and assess their prognostic value over Ki67.
Materials and methods: Retrospective study of 121 PCs (104 Typical; TCs and 17 Atypical; ACs). The expression of growth factors was studied immunohistochemically and tumors were considered positive if immunoreactivity appeared in >50% of cells.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - Signaling pathways, receptors, biomarkers
Presenting Author: M.D, Ph.D. Apostolos Tsolakis
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