Carcinoid Heart Disease (CHD): Prognostic Value of 5-HIAA and Impact on Survival – A Systematic Literature Review

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Introduction: CHD is a life threatening complication of carcinoid syndrome. Its exact pathophysiology is uncertain but several studies have identified serotonin as a potential key mediator. The amount of serotonin production can be assessed by the dosage of its metabolite 5-HIAA in urine or plasma.

Aim(s): To summarize the evidence quantifying the risk of CHD development associated to high 5-HIAA levels and the impact of CHD on survival.

Materials and methods: A systematic search of MEDLINE, EMBASE and the Cochrane Library databases was conducted. Articles were screened by two independent reviewers using defined inclusion and exclusion criteria.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Singh S

Authors: Haig J, Kohli M, Pastor L, Feuilly M, Marteau F,

Keywords: 5-HIAA, prognosis, carcinoid heart disease, survival,