Case Report of Recurrent VIPoma Abstract #1248

Introduction: 51yr presented with 7 month diarrhoea&2 stone weight loss. All tests negative, only abnormality hypokalaemia. FGH profile: VIP raised>400, peptide histidine methionine>1000, GAWK of 250. Diagnosis of VIPoma. CT: 5cm mass tail & body of pancreas, no hepatic or adrenal lesions. Octreotide treatment started. Bowel frequency improved, hypokalaemia corrected. Octreotide scan showed uptake only in pancreas. Patient readmitted 5 months later hypokalaemic myopathy, K 1.7, surgical distal pancreatectomy & splenectomy completed. Histology: NET within pancreas, moderate cellular differentiation, variable mitotic rate.
Aim(s): Tumour enclosed in capsule, showed capsular invasion. Patient discharged, followed-up 9yr, no signs of recurrence.
Materials and methods: 11yr on patient referred on cancer pathway with diarrhoea, no electrolyte changes. Colonoscopy: normal. CT: tumour recurrence in pancreatic bed. CgA120, CgB89, VIP130, other FGH normal. Ocreotide scan: uptake left upper quadrant & epigastrium. USS biopsy: NET minimal cellular differentiation, no evidence mitotic activity, positive chromogranin & synaptophysin, low Ki67 <5%.
Conference: 12th Annual ENETS Conference (2015)
Category: Clinical cases/reports
Presenting Author: Dr Victoria Mulcahy
Keywords: VIPoma

To read results and conclusion, please login ...

Further abstracts you may be interested in

#244 Challenges in the Management of VIPoma Patients
Introduction: VIPomas are a rare neuroendocrine tumor (NET). 90% are pancreatic. 40-70% are metastatic at presentation. The VIPoma syndrome is characterized by secretory diarrhoea, hypokalaemia and achlorhydria.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: Dr Fatima El-Khouly
#983 Vipomas: Report of Three Cases in Ten Years
Introduction: VIPoma is a rare neuroendocrine tumor (NET) with an incidence of one in 10 million per year. Most cases arise within the pancreas, with others reported in the lungs, colon, liver, adrenals, and neuroganglia.
Conference: 11th Annual ENETS Conference (2014)
Category: Surgical treatment
Presenting Author: Prof. Claudio Pasquali
#1535 VIPomas, a Rare Entity
Introduction: VIP secreting pancreatic neuroendocrine tumors(pNETs) are rare and controlled studies are lacking.
Conference: 13th Annual ENETS conference (2016)
Category: Epidemiology/Natural history/Prognosis - Descriptive epidemiology
Presenting Author: MD,PhD Georgios Boutzios
Keywords: VIPoma, pNET
#1738 Sinonasal Neuroendocrine Small Blue Cell Tumour (SNBCT) Presenting with Bone Marrow Failure – A Very Rare Diagnostic and Therapeutic Challenge
Introduction: A 75 year old female presented with rapid onset right neck swelling and nasal bleeding. CT showed an infiltrative soft tissue mass involving the entire right nasal cavity and a lymph node mass in the right neck.
Conference: 14th Annual ENETS conference (2017)
Category: Clinical cases/reports
Presenting Author: Dr Simon Duke
Authors: Dawes A, Duke S, Tahir Q, Leitch J, ...
#2110 Pancreatic VIPomas: Reported Cases From China Since 1980
Introduction: Vasoactive intestinal polypeptide (VIP)-secreting tumors (VIPoma) are rare neuroendocrine tumors with distinct clinic presentation.
Conference: 15th Annual ENETS conference (2018)
Category: Case reports
Presenting Author: MD Chuyan Chen
Authors: Chen C, Zheng Z, Xie Y, Zheng C, ...
Keywords: VIPoma, NET, somatostatin