Change of Lactate Transporter (MCT4) Expression in Pancreatic Microadenomas and Stages of Pancreatic Neuroendocrine Tumors

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Introduction: Metabolic changes are observed in early and late stages of Pancreatic Neuroendocrine Tumors (PanNET) in mouse models. In human PanNET, RNA-expression analysis showed changes in glucose metabolism in more aggressive PanNET.

Aim(s): We investigated the expression of the lactate transporter Monocarboxylate Transporter 4 (MCT4) in pancreatic microadenomas, neuroendocrine tumors of different stages and carcinomas (NEC) as a potential metabolic surrogate marker for glucose usage.

Materials and methods: We assessed the expression of MCT4 by immunohistochemistry in 81 pancreatic microadenomas from seven MEN1 patients and one VHL patient as well as 106 sporadic PanNET. Expression levels were correlated with clinico-pathological features.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Bräutigam K

Authors: Straub J, Bräutigam K, Di Domenico A, Galván J, Maire R,

Keywords: metabolism, microadenoma, immunohistochemistry, pancreas, tumor, mct4, relapse,