Characterisation, Measurement and Biodistribution of an Improved Formulation of [Lu-177]-Octreotate Abstract #1156

Introduction: Lu-177 can be made with high specific activity and no other isotopes of lutetium present, referred to as “no carrier added” (nca) Lu-177. We have radiolabelled DOTA-conjugated peptide DOTA‐(Tyr3)‐octreotate (Auspep, Melb., AUS) with nca Lu-177 (“nca-LuTATE”) and used it in over 30 administrations in NETs patients.
Aim(s): Initial report on the accuracy, biodistribution and dosimetry of nca-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) Lu-177 imaging.
Materials and methods: Ten patients received >30 nca-LuTATE injections made with an E&Z PharmTracer automated module. Extensive WB planar and qSPECT imaging was validated in vivo at 0.5, 4, 24 and 96 hrs to permit estimates of radiation dose using MIRD-based methodology (OLINDA-EXM).
Conference: 12th Annual ENETS Conference (2015)
Category: Imaging (radiology, nuclear medicine, endoscopy)
Presenting Author: Professor Dale Bailey

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