Chomogranin A, NSE, and 5-Hydroxyindolacetic Acid Measurements in Malignant Carcinoids Abstract #640

Introduction: GEP-NETs are a heterogeneous group of cancers more common in the small intestine which are usually asymptomatic. In patients with malignant carcinoids, a number of tumor markers (TMs) have been considered enclosing urinary 5-hydroxyindolacetic acid (5-HIAA), chromogranin A (CgA), and neuron-specific enolase (NSE) serum levels measurements. Unfortunately, the sensitivity of each TM largely depends on disease extent and the presence of functioning tumors, and thus their usefulness is still unclear.
Aim(s): To find a relationship between CgA, NSE, 5-HIAA and survival in patients with gastrointestinal carcinoids.
Materials and methods: Data regarding 14 patients (8 men, 6 women, median age 56 years, range 33-72) with histologically confirmed gastric (N=8), ileal (N=1), colorectal (N=4) and appendiceal (N=1) malignant carcinoids were reviewed. All patients underwent surgery, and four had liver metastases at the time of diagnosis.
Conference: 10th Annual ENETS Conference (2013)
Category: Biomarkers
Presenting Author: Professor Franco Lumachi

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