Circulating Neuroendocrine Gene Transcripts (NETest) Decrease Early after Radical Surgery: Preliminary Results of a Prospective Study

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Introduction: Specific biomarkers for predicting response and risk of recurrence after surgery for enteropancreatic neuroendocrine tumours (EP-NETs) are still lacking.

Aim(s): Aim of this prospective study was to evaluate if blood measurement of neuroendocrine gene transcripts (NETest) correlates with the efficacy of surgical resection for EP-NET.

Materials and methods: Between April and November 2017, all patients affected by EP-NETs scheduled for surgery were enrolled in this prospective study (NCT 03012789). Whole blood samples for NETest and plasma for Chromogranin A (CgA) were collected preoperatively and on postoperative day 1 (POD1) and 5 (POD5). Transcripts were blinding measured by real-time quantitative reverse transcription PCR (qRT-PCR) and multianalyte algorithmic analysis (NETest); CgA by enzyme-linked immunosorbent assay (ELISA).

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Partelli S

Authors: Partelli S, Kidd M, Muffatti F, Andreasi V, Giannone F,

Keywords: NETest, biomarker, Enteropancreatic Neuroendocrine Tumors, diagnosis, surgery,