CK 19 Expression in Pancreatic Neuroendocrine Tumors as Negative Prognostic Factor and a Risk Factor for Metastases

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Introduction: Neuroendocrine tumors (NET) of the pancreas are slow growing neoplasms, but they can metastasize after many years after surgery.

Aim(s): To evaluate the role of cytokeratin 19 (CK 19) expression in NETs of different origin.

Materials and methods: We conducted a comparative study of CK19 expression in 211 NET specimens: pancreas - 118, gut - 35, lung - 21, stomach - 15, thymus - 6, metastases with unknown primary localization -16. Metastases were revealed in 28 cases NET of the pancreas (23,7%), in 15 (42,9%) - gut, in 10 (66,7%) -stomach, in 6 (28,6%) - lung and in 3 (50%) - thymus.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Gurevich L, Korsakova N, Kazantseva I, Bobrov M, Egorov A,

Keywords: neuroendocrine tumors, CK19 expression, immunohischemistry, prognosis.,

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