CK19 and KIT Immunostaining is a Useful Adjunct to Ki-67-Based Grading of Pancreatic NET: A Study on Matched Cytological and Histological Samples

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Introduction: Pancreatic neuroendocrine tumors (NET) are rare neoplasms. Recent evidence suggests that Ki-67 staining predicts their behavior. Even more recently, a prognostic role has been proposed also for CK19 and KIT. This panel might guide patient management. CK19 and KIT have not yet been evaluated on NET on Fine needle aspiration samples (FNAs).

Aim(s): To assess the feasibility of CK19 and KIT immunostaining assessment on pancreatic FNAs.

Materials and methods: Nine patients underwent EUS-FNA examination before surgery for primary (n=7) and metastatic (n=2) pancreatic NET. On site evaluation by an experienced cytopathologist ensured proper tissue handling for the prepration of a representative cell block for immunostainings. These latter were compared to those performed on the matched resected samples.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Bellevicine C, Iaccarino A, Faggiano A, Napolitano V, Colao A,

Keywords: FNA, pancreas, NET, Ki-67, Kit, CK19,