Clinical and Immunohistochemical Evaluation of Medullary Thyroid Cancer (MTC) and C Cell Hyperplasia (CCH)

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Introduction: MTC and CCH has a variable clinical presentation and prognosis and no data are available on the correlation between immunoistochemical (IIC) characterization and clinical behavior.

Aim(s): Evaluation of clinical behavior, prognosis and IIC expression (PTTG-1, SSTR2A, VEGFR-1, -2 and -3) in 23 patients affected by MTC and/or CCH.

Materials and methods: Twenty-three patients affected by MTC and/or CCH were included. All patients underwent total thyroidectomy, pre- and post-operative calcitonin assay, staging, histological examination, IIC evaluation of expression of PTTG-1, SSTR2A, VEGFR-1, -2 and -3.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Lugli F, Fusco A, Bianchi A, Milardi D, Lanza P,

Keywords: CCH, MTC, PTTG-1, SSTR2A, VEGFR-1, VEGFR-2, VEGFR-3, IIC, staging, prognosis, therapy,