Clinical value of MRI DWI and (Gd-EOB)-DTPA to assess liver involvement in patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs)

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Introduction: Standard MRI, including breath-hold techniques with SE T1 and T2 weighted images, biochemical shift, and 3D GRE and also T1 images after gadolinium enhancement Gd-DTPA, are useful in detecting liver lesions in patients with advanced GEP-NET. Recently, new algorithms of MRI, including diffusion-weighted imaging MRI (DWI) and i.v. (Gd-EOB)-DTPA (Primovist) contrast enhancement, seems to be promising in the detection of liver deposits.

Aim(s): The detection rate of liver metastasis in patients with advanced GEP-NET, using standard SE T2 weighted images, compared to new algorithms diffusion-weighted imaging (DWI) and MRI after i.v. contrast enhancement (Gd-EOB)-DTPA.

Materials and methods: Study group 36pts, all had confirmed neuroendocrine tumors (GEP-NET), mean age 55.4 yrs, there were 20 females and 16 males. All had CS IV with liver involvement. All had MRI examination as a part of the standard clinical evaluation of disease extent (staging and restaging) and also to assess efficacy of therapy. All had PRRT using 90Y DOTATATE, 24 had previous and current ""cold"" analogues SST therapy. All pts had examinations using the same system 1.5T MRI, using the same protocol with DWI and other sequences of examination. Standard dose of contrast agent (Gd-EOB)-DTPA was used in each case, with administration recommended by manufactures.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Cwikla J, Sankowski A, Nowicki M, Lewczuk A, Nasierowska-Guttmejer A,

Keywords: GEP-NET, MRI, diffusion-weighted imaging - DWI), (Gd-EOB)-DTPA ,