Co-Expression of Somatostatin and CXCR4 Receptors as Targets for Diagnostics and Treatment in Intestinal Neuroendocrine Neoplasms. Abstract #1038

Introduction: Somatostatin receptors (SSTR) are widely distributed in well-differentiated neuroendocrine tumors (NET) and serve as primary targets for diagnostics and treatment. An overexpression of the chemokine receptor CXCR4, in contrast, is considered to be present mainly in highly proliferative and advanced carcinomas.
Aim(s): Comparative data are still lacking, however, for neuroendocrine carcinomas (NEC).
Materials and methods: SSTR subtypes (1, 2A, 3, 5) and CXCR4 expression was evaluated in G1 (n=31), G2 (n=47) and low (G3a; Ki-67: 21-49%) and highly proliferative (G3b; Ki-67: >50%) G3 (n=43) neuroendocrine neoplasms by means of immunohistochemistry using novel monoclonal rabbit anti-human anti-SSTR and anti-CXCR4 antibodies and correlated to clinical data.
Conference: 12th Annual ENETS Conference 2015 (2015)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Dr. Daniel Kaemmerer
Keywords: sstr

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