Comparison of Response Evaluation in Patients with Gastroenteropancreatic and Thoracic Neuroendocrine Tumors after Treatment with [177Lu-DOTA0,Tyr3]Octreotate

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Introduction: Response Evaluation Criteria in Solid Tumors (RECIST) (unidimensional), Southwest Oncology Group (SWOG) solid tumor response criteria (bidimensional), and their modified variants (mRECIST/mSWOG) are used to assess treatment response in gastroenteropancreatic and thoracic neuroendocrine tumors (NETs).

Aim(s): To compare the RECIST, SWOG, mRECIST and mSWOG criteria in NET patients treated with [177Lu-DOTA0,Tyr3]octreotate (177Lu-octreotate).

Materials and methods: CT/MRI scans of 268 NET patients, treated with 177Lu-octreotate, were analyzed using RECIST, SWOG, mRECIST and mSWOG criteria (including the response class minor response (MR) (decrease of 13-30% for mRECIST and 25-50% for mSWOG)). The outcomes were correlated with overall survival (OS).

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Van Vliet E, Krenning E, Teunissen J, Bergsma H, Kam B,

Keywords: net, PRRT, response criteria,