CT-Guided HDR Brachyterapy in Patients with Advanced Non-Resectable and Progressive NEN with Liver Bulky Disease. Pilot Study

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Introduction: CT-Guided HDR Brachyterapy is a new method used for liver metastases treatment.

Aim(s): The aim of the study was the evaluation of CT (fluoroscopy) guided application of High Dose Rate (HDR) brachytherapy in patients with non-resectable, progressive NEN, with liver involvement.

Materials and methods: 9 patients, 6 males, all with heavy pretreatment history, with a few therapy regiments, mean age 52.0. GEP-NEN seven, single atypical carcinoid (AC) and malignant paraganglioma (PGL1). All with liver involvement, additionally 4 of them had secretory tumors. There were NETG1 (1), G2 (7) and single NETG3. Overall 15 HDR proceedings were conducted. The clinical and radiological evaluation (RECIST 1.0) were used to assess efficacy. PFS and OS during clinical follow-up were calculated using Kaplan-Meier. AEs (CTCAE 4.0) and the frequency of occurrence of radiotherapy related early morbidity using RTOG.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Kieszko D, Cisek P, Kolasińska-Ćwikła A, Bednarczuk T, Nowicki M,

Keywords: advanced non-resectable neuroendocrine neoplams, CT image guided HDR Brachytherapy,