CXCR4 Expression on Circulating Tumor Cells (CTCs) and Their Association with Bone Metastases in Patients with Neuroendocrine Tumors (NET) Abstract #2022

Introduction: Bone metastases have been described in up to 32% of NET patients and are associated with a worse clinical outcome. Overexpression of CXCR4 in primary tumors appears predictive of skeletal involvement.
Aim(s): Here we investigate the role of CTCs as a marker of bone metastases and evaluate the expression of CXCR4 on CTCs as a potential predictor for skeleton invasion.
Materials and methods: Eligible patients were required to have histologically confirmed bronchial, midgut or pancreatic NET and metastatic disease by RECIST. Clinicopathological data were collected. Patients provided 7.5 mL blood samples which were analyzed by CellSearch. CXCR4 immunohistochemistry was performed on matched FFPE samples.
Conference: 15th Annual ENETS conference 2018 (2018)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: Francesca Maria Rizzo
Keywords: CTC, CXCR4, bone

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